QR-6401 is a selective macrocyclic inhibitor of cyclin-dependent kinase 2 (CDK2), demonstrating an IC50 of 0.37 nM for CDK2/E1 and exhibiting varying activity against other CDKs. This compound shows potent antitumor efficacy in an OVCAR3 ovarian cancer xenograft model. QR-6401 is valuable for research into cancer mechanisms and potential therapeutic approaches targeting CDK2.
QR-6401 is a selective macrocyclic inhibitor of cyclin-dependent kinase 2 (CDK2), demonstrating an IC50 of 0.37 nM for CDK2/E1 and exhibiting varying activity against other CDKs. This compound shows potent antitumor efficacy in an OVCAR3 ovarian cancer xenograft model. QR-6401 is valuable for research into cancer mechanisms and potential therapeutic approaches targeting CDK2.
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