Quizartinib-d8 is a deuterium-labeled derivative of Quizartinib, a selective and potent type II FLT3 tyrosine kinase inhibitor. With a Kd of 1.6 nM, Quizartinib effectively inhibits both wild-type FLT3 and FLT3-ITD autophosphorylation, exhibiting IC50 values of 4.2 and 1.1 nM, respectively, in MV4-11 cells. This reagent is valuable in research applications involving targeted protein degradation when linked to VHL ligands through optimized linkers. Additionally, Quizartinib is known to induce apoptosis, highlighting its potential in therapeutic strategies for hematological malignancies.
Quizartinib-d8 is a deuterium-labeled derivative of Quizartinib, a selective and potent type II FLT3 tyrosine kinase inhibitor. With a Kd of 1.6 nM, Quizartinib effectively inhibits both wild-type FLT3 and FLT3-ITD autophosphorylation, exhibiting IC50 values of 4.2 and 1.1 nM, respectively, in MV4-11 cells. This reagent is valuable in research applications involving targeted protein degradation when linked to VHL ligands through optimized linkers. Additionally, Quizartinib is known to induce apoptosis, highlighting its potential in therapeutic strategies for hematological malignancies.
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