Fig. 1 · Structure
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(R)-Afatinib
Afatinib Isomer
(R)-Afatinib is a potent and irreversible dual specificity inhibitor targeting the ErbB family, specifically EGFR and HER2. With IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM for EGFR wild type, EGFR L858R, EGFR L858R/T790M, and HER2, respectively, this compound exhibits significant biological activity against these receptors. (R)-Afatinib is utilized in research focused on esophageal squamous cell carcinoma, non-small cell lung cancer, and gastric cancer, providing essential insights into targeted therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 439081-17-1 |
| Applications | Afatinib Isomer |
| Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 |
| Synonyms | (R)-BIBW 2992 |
| SMILES | CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)F)=NC=N3)=C3C=C1O[C@@H]4CCOC4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.