(R)-Afatinib is a potent and irreversible dual specificity inhibitor targeting the ErbB family, specifically EGFR and HER2. With IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM for EGFR wild type, EGFR L858R, EGFR L858R/T790M, and HER2, respectively, this compound exhibits significant biological activity against these receptors. (R)-Afatinib is utilized in research focused on esophageal squamous cell carcinoma, non-small cell lung cancer, and gastric cancer, providing essential insights into targeted therapies.
(R)-Afatinib is a potent and irreversible dual specificity inhibitor targeting the ErbB family, specifically EGFR and HER2. With IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM for EGFR wild type, EGFR L858R, EGFR L858R/T790M, and HER2, respectively, this compound exhibits significant biological activity against these receptors. (R)-Afatinib is utilized in research focused on esophageal squamous cell carcinoma, non-small cell lung cancer, and gastric cancer, providing essential insights into targeted therapies.
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