(R)-DPN is a selective ligand for estrogen receptor beta (ERβ), exhibiting an EC50 of 0.8 nM for ERβ and significantly higher affinity compared to ERα, with an EC50 of 2.9 nM. This compound demonstrates notable cytotoxic effects in HEC-1 and U2OS cell lines, with EC50 values of 286 nM and 205 nM, respectively. (R)-DPN is invaluable for research in hormonal regulation, cancer biology, and the exploration of ERβ signaling pathways.
(R)-DPN is a selective ligand for estrogen receptor beta (ERβ), exhibiting an EC50 of 0.8 nM for ERβ and significantly higher affinity compared to ERα, with an EC50 of 2.9 nM. This compound demonstrates notable cytotoxic effects in HEC-1 and U2OS cell lines, with EC50 values of 286 nM and 205 nM, respectively. (R)-DPN is invaluable for research in hormonal regulation, cancer biology, and the exploration of ERβ signaling pathways.
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