(R)-OP-1074 is an isomer of OP-1074, designed as a control compound for experimental studies. It serves as a valuable tool in evaluating the selective estrogen receptor degradation activity of OP-1074, a potent anti-estrogen drug. Specifically, OP-1074 acts as a selective ER degrader with demonstrated anti-estrogenic effects against both estrogen receptors ERα and ERβ, inhibiting 17β-estradiol (E2)-stimulated transcription at IC50 values of 1.6 and 3.2 nM, respectively. Its role in research applications includes studies on hormone signaling and estrogen receptor biology.
(R)-OP-1074 is an isomer of OP-1074, designed as a control compound for experimental studies. It serves as a valuable tool in evaluating the selective estrogen receptor degradation activity of OP-1074, a potent anti-estrogen drug. Specifically, OP-1074 acts as a selective ER degrader with demonstrated anti-estrogenic effects against both estrogen receptors ERα and ERβ, inhibiting 17β-estradiol (E2)-stimulated transcription at IC50 values of 1.6 and 3.2 nM, respectively. Its role in research applications includes studies on hormone signaling and estrogen receptor biology.
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