(R)-Pirlindole mesylate is a selective and reversible inhibitor of Monoamine oxidase A (MAO-A), exhibiting an IC50 of 0.43 μM against MAO-A with minimal effect on MAO-B. This compound demonstrates notable antidepressant activity, as evidenced by a significant reduction in immobility time in the forced swim test. Additionally, (R)-Pirlindole mesylate effectively inhibits Reserpine-induced palpebral ptosis in behavioral mice models. Its properties make it a valuable tool for research into depression and related disorders.
(R)-Pirlindole mesylate is a selective and reversible inhibitor of Monoamine oxidase A (MAO-A), exhibiting an IC50 of 0.43 μM against MAO-A with minimal effect on MAO-B. This compound demonstrates notable antidepressant activity, as evidenced by a significant reduction in immobility time in the forced swim test. Additionally, (R)-Pirlindole mesylate effectively inhibits Reserpine-induced palpebral ptosis in behavioral mice models. Its properties make it a valuable tool for research into depression and related disorders.
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