(R,S,R)-ML334 is the isomer of ML334, serving as a valuable experimental control in research. This compound acts primarily as a cell-permeable activator of NRF2 by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity of 1 µM to the Kelch domain of Keap1, (R,S,R)-ML334 enhances NRF2 expression, promotes its nuclear translocation, and induces antioxidant response elements (ARE) activity, making it significant for studies related to oxidative stress and cellular defense mechanisms.
(R,S,R)-ML334 is the isomer of ML334, serving as a valuable experimental control in research. This compound acts primarily as a cell-permeable activator of NRF2 by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity of 1 µM to the Kelch domain of Keap1, (R,S,R)-ML334 enhances NRF2 expression, promotes its nuclear translocation, and induces antioxidant response elements (ARE) activity, making it significant for studies related to oxidative stress and cellular defense mechanisms.
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