R547

Catalog No.: A11190
CDK inhibitor

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

Grouped product items
Product Name Price Stock Qty
R547 5mg
$68.00
In stock
R547 25mg
$204.00
In stock
R547 50mg
$680.00
In stock
R547 10mM * 1mL in DMSO
$214.00
In stock
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Biological Activity
Discription

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

Targets
Target Value
Product Information
Catalog Num A11190
Formula C18H21F2N5O4S
Molecular Weight 441.45
CAS Number 741713-40-6
SMILES COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C
Synonyms R-547
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 56 mg/mL (126.85 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% hydroxyethyl cellulose+0.2% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.65 mL 113.26 mL 226.53 mL
0.5 mM 4.53 mL 22.65 mL 45.31 mL
1 mM 2.27 mL 11.33 mL 22.65 mL
5 mM 0.45 mL 2.27 mL 4.53 mL
Useful Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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