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R547

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CDK inhibitor

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Catalog No. A11190

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
R547 2mg A11190-2

Regular Price: €66.50

Special Price: €59.85

R547 5mg A11190-5

Regular Price: €114.00

Special Price: €102.60

R547 25mg A11190-25

Regular Price: €380.00

Special Price: €342.00

R547 50mg A11190-50

Regular Price: €684.00

Special Price: €615.60

R547 10mM * 1mL in DMSO A11190-10mM-D

Regular Price: €203.30

Special Price: €182.97

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

R547

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Chemical Information

Catalog Num A11190
Actions Inhibitor
M. Wt 441.45
Formula C18H21F2N5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 741713-40-6
Synonyms R-547
SMILES code COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C
Chemical Name [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone

Biological Activity

Description

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.
Targets
Target Value
CDK4/CyclinD1ki: 1nM
CDK1/CyclinBki: 2nM
CDK2/CyclinEki: 3nM
PKAki: >5μM
PKBki: >5μM
PKCαki: >5μM
PKCβki: >5μM
Fynki: >5μM
EphB3ki: >5μM
SGKki: >5μM
KDRki: >5μM
FGFRki: >5μM
EGFRki: >5μM
PDGFRki: >5μM
IGFRki: >5μM
Srcki: >5μM
FAKki: >5μM
AuroraAki: >5μM
GSK-3βki: 8μM
p38ki: >50μM
MAPK2ki: >50μM

Solubility

Solubility (25°C) * In vitro DMSO 60 mg/mL (135.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% hydroxyethyl cellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.65 mL 113.26 mL 226.53mL
0.5 mM 4.53 mL 22.65 mL 45.31 mL
1 mM 2.27 mL 11.33 mL 22.65 mL
5 mM 0.45 mL 2.27 mL 4.53 mL

*The above data is based on the productmolecular weight 441.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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