R788 (Fostamatinib)

Catalog No.: A11926

Syk inhibitor

R788 (Fostamatinib)

R788 (Fostamatinib) Chemical Structure

CAS NO. 901119-35-5

R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling.

Availability: In stock

Package Price Qty
2 mg
$60.00
5 mg
$100.00
10 mg
$180.00
25 mg
$400.00
10mM * 1mL in DMSO
$233.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Mahon OR, .et al. Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner, Acta Biomater, 2018, Jan;65:426-435 PMID: 29104084
  • Emma M. Corr, .et al. Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells, Arthritis Res Ther, 2017, 19: 23 PMID: 28173838
  • Cunningham CC, .et al. Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling, Osteoarthritis Cartilage, 2016, Dec;24(12):2141-2152 PMID: 27426968
  • Corr EM, .et al. Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells, Atherosclerosis, 2016, Aug;251:197-205 PMID: 27356299

Biological Activity

R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling.
Targets
Syk Adenosine A3 receptor Adenosine transporter Monoamine transporter
41 nM81 nM1.84 μM2.74 μM
In vitro (25°C) DMSO 116 mg/mL (199.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.23 mL 86.13 mL 172.27 mL
0.5 mM 3.45 mL 17.23 mL 34.45 mL
1 mM 1.72 mL 8.61 mL 17.23 mL
5 mM 0.34 mL 1.72 mL 3.45 mL

*The above data is based on the productmolecular weight 580.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11926
Actions Inhibitor
M. Wt 580.5
Formula C23H26FN6O9P
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 901119-35-5
Synonyms R-788
SMILES CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C

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