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R935788 (Fostamatinib disodium, R788)

Catalog No.: A10771

Syk Inhibitor

R935788 (Fostamatinib disodium, R788)

R935788 (Fostamatinib disodium, R788) Chemical Structure

CAS NO. 1025687-58-4

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$130.00
50 mg
$400.00
100 mg
$638.00
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Biological Activity

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
Targets
Syk (Cell-free assay)
41 nM
In vitro (25°C) DMSO Warmed: 5 mg/mL (8 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% CMC+0.25% Tween 80,pH6.5 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.02 mL 80.08 mL 160.15 mL
0.5 mM 3.2 mL 16.02 mL 32.03 mL
1 mM 1.6 mL 8.01 mL 16.02 mL
5 mM 0.32 mL 1.6 mL 3.2 mL

*The above data is based on the productmolecular weight 624.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10771
Actions Inhibitor
CAS No. 1025687-58-4
Formula C23H24FN6O9P.2Na
M. Wt 624.4
Purity >98%
Synonyms R-935788, Fostamatinib disodium, R788
SMILES CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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