R935788 (Fostamatinib disodium, R788)

Catalog No.: A10771

Syk Inhibitor

R935788 (Fostamatinib disodium, R788) Chemical Structure

CAS NO. 1025687-58-4

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$130.00
50 mg
$400.00
100 mg
$638.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
Targets
Syk (Cell-free assay)
41 nM
In vitro (25°C) DMSO 0.4 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80,pH6.5 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.02 mL 80.08 mL 160.15 mL
0.5 mM 3.2 mL 16.02 mL 32.03 mL
1 mM 1.6 mL 8.01 mL 16.02 mL
5 mM 0.32 mL 1.6 mL 3.2 mL

*The above data is based on the productmolecular weight 624.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10771
Actions Inhibitor
M. Wt 624.4
Formula C23H24FN6O9P.2Na
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1025687-58-4
Synonyms R-935788, Fostamatinib disodium, R788
SMILES CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]

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