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Biological Activity
R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
Targets
| Syk (Cell-free assay) | ||||
| 41 nM |
| In vitro (25°C) | DMSO | Warmed: 5 mg/mL (8 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% CMC+0.25% Tween 80,pH6.5 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.02 mL | 80.08 mL | 160.15 mL |
| 0.5 mM | 3.2 mL | 16.02 mL | 32.03 mL |
| 1 mM | 1.6 mL | 8.01 mL | 16.02 mL |
| 5 mM | 0.32 mL | 1.6 mL | 3.2 mL |
*The above data is based on the productmolecular weight 624.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10771 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1025687-58-4 |
| Formula | C23H24FN6O9P.2Na |
| M. Wt | 624.4 |
| Purity | >98% |
| Synonyms | R-935788, Fostamatinib disodium, R788 |
| SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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