RAF709

Catalog No.: A16842

raf kinase inhibitor

RAF709

RAF709 Chemical Structure

CAS NO. 1628838-42-5

RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
50 mg
$440.00
100 mg
$715.00
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Biological Activity

RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.
In vitro DMSO 86 mg/mL (158.51 mM)
Water Insoluble
Ethanol 86 mg/mL (158.51 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.43 mL 92.16 mL 184.31 mL
0.5 mM 3.69 mL 18.43 mL 36.86 mL
1 mM 1.84 mL 9.22 mL 18.43 mL
5 mM 0.37 mL 1.84 mL 3.69 mL

*The above data is based on the productmolecular weight 542.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16842
Actions Inhibitor
CAS No. 1628838-42-5
Formula C28H29F3N4O4
M. Wt 542.55
Purity >98%
Synonyms RAF 709, RAF-709
SMILES O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC(C(F)(F)F)=CC=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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