Ranitidine bismuth citrate is a selective, orally active antagonist of the histamine H2 receptor, primarily used to inhibit gastric acid secretion. This compound effectively blocks histamine-induced contractile responses in the guinea-pig isolated rat atrium and relaxations in the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Additionally, ranitidine bismuth citrate demonstrates antiviral activity against SARS-CoV-2-infected cells and exhibits efficacy against Helicobacter pylori infections. Furthermore, it has been shown to inhibit breast tumor development and dissemination in murine models.
Ranitidine bismuth citrate is a selective, orally active antagonist of the histamine H2 receptor, primarily used to inhibit gastric acid secretion. This compound effectively blocks histamine-induced contractile responses in the guinea-pig isolated rat atrium and relaxations in the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Additionally, ranitidine bismuth citrate demonstrates antiviral activity against SARS-CoV-2-infected cells and exhibits efficacy against Helicobacter pylori infections. Furthermore, it has been shown to inhibit breast tumor development and dissemination in murine models.
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