RANKL-IN-2 is a selective inhibitor of RANKL, exhibiting Kd values of 3.21 μM and 4.625 μM in surface plasmon resonance and microscale thermophoresis assays, respectively. By binding to RANKL, it disrupts the RANKL-RANK interaction, thereby suppressing osteoclastogenesis through the inhibition of reactive oxygen species, MAPK, and NF-κB signaling pathways. RANKL-IN-2 demonstrates efficacy in preventing RANKL-induced osteoclast formation, bone resorption, and the expression of osteoclast-specific genes and proteins in vitro. Additionally, RANKL-IN-2 has shown potential in preventing bone loss in ovariectomized mouse models, making it a valuable tool for osteoporosis research.
RANKL-IN-2 is a selective inhibitor of RANKL, exhibiting Kd values of 3.21 μM and 4.625 μM in surface plasmon resonance and microscale thermophoresis assays, respectively. By binding to RANKL, it disrupts the RANKL-RANK interaction, thereby suppressing osteoclastogenesis through the inhibition of reactive oxygen species, MAPK, and NF-κB signaling pathways. RANKL-IN-2 demonstrates efficacy in preventing RANKL-induced osteoclast formation, bone resorption, and the expression of osteoclast-specific genes and proteins in vitro. Additionally, RANKL-IN-2 has shown potential in preventing bone loss in ovariectomized mouse models, making it a valuable tool for osteoporosis research.
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