Raxatrigine (GSK1014802)

Catalog No.: A13020

Sodium channel blocker

Raxatrigine (GSK1014802)

Raxatrigine (GSK1014802) Chemical Structure

CAS NO. 934240-30-9

Raxatrigine (GSK1014802) is a novel sodium channel blocker and is an effective anticonvulsant agent. In rats, GSK1014802 (20 - 80 mg/kg p.o.) attenuated the deficit in reversal learning induced by phencyclidine (PCP) in a dose-dependent way, which suggested the potential of GSK1014802 in the treatment of cognitive symptoms of schizophrenia. GSK2 was also a potent inhibitor of human MAO-B with pIC50 value of 7.96 but did not inhibit human MAO-A.

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5 mg
$160.00
25 mg
$320.00
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Biological Activity

Raxatrigine (GSK1014802) is a novel sodium channel blocker and is an effective anticonvulsant agent. In rats, GSK1014802 (20 - 80 mg/kg p.o.) attenuated the deficit in reversal learning induced by phencyclidine (PCP) in a dose-dependent way, which suggested the potential of GSK1014802 in the treatment of cognitive symptoms of schizophrenia. GSK2 was also a potent inhibitor of human MAO-B with pIC50 value of 7.96 but did not inhibit human MAO-A.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.81 mL 159.06 mL 318.12 mL
0.5 mM 6.36 mL 31.81 mL 63.62 mL
1 mM 3.18 mL 15.91 mL 31.81 mL
5 mM 0.64 mL 3.18 mL 6.36 mL

*The above data is based on the productmolecular weight 314.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13020
Actions Blocker
CAS No. 934240-30-9
Formula C18H19FN2O2
M. Wt 314.35
Purity >98%
Synonyms GSK1014802, GSK-1014802, GSK 1014802
SMILES FC1=CC=CC=C1COC2=CC=C([[email protected]@](N3)([H])CC[[email protected]@]3([H])C(O)=N)C=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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