rel-(R,R)-THC is an isomeric compound characterized by its distinct (R,R) configuration. It selectively acts as an agonist for estrogen receptor alpha (ERα) and as an antagonist for estrogen receptor beta (ERβ), exhibiting binding affinities with Ki values of 9.0 nM and 3.6 nM, respectively. This compound's higher binding affinity for ERβ compared to ERα, with values of 25 nM and 3.6 nM, positions it as a valuable tool for research into estrogen receptor modulation and related signaling pathways.
rel-(R,R)-THC is an isomeric compound characterized by its distinct (R,R) configuration. It selectively acts as an agonist for estrogen receptor alpha (ERα) and as an antagonist for estrogen receptor beta (ERβ), exhibiting binding affinities with Ki values of 9.0 nM and 3.6 nM, respectively. This compound's higher binding affinity for ERβ compared to ERα, with values of 25 nM and 3.6 nM, positions it as a valuable tool for research into estrogen receptor modulation and related signaling pathways.
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