Relugolix

Catalog No.: A17783

GnRH antagonist

Relugolix

Relugolix Chemical Structure

CAS NO. 737789-87-6

Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013.

Availability: In stock

Package Price Qty
1 mg
$60.00
5 mg
$110.00
10 mg
$180.00
50 mg
$600.00
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Biological Activity

Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013.
In vitro DMSO 59 mg/mL (94.6 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.04 mL 80.18 mL 160.35 mL
0.5 mM 3.21 mL 16.04 mL 32.07 mL
1 mM 1.6 mL 8.02 mL 16.04 mL
5 mM 0.32 mL 1.6 mL 3.21 mL

*The above data is based on the productmolecular weight 623.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17783
Actions Antagonist
CAS No. 737789-87-6
Formula C29H27F2N7O5S
M. Wt 623.63
Purity >98%
Synonyms TAK385; TAK-385; TAK 385; Relugolix.
SMILES O=C(NOC)NC1=CC=C(C(S2)=C(CN(C)C)C(C(N3C4=NN=C(OC)C=C4)=O)=C2N(CC5=C(F)C=CC=C5F)C3=O)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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