Retinoic acid-d5 is a deuterium-labeled derivative of retinoic acid, functioning as a selective retinoic acid receptor (RAR) agonist. It is crucial for cellular processes such as growth, differentiation, and organogenesis, demonstrating IC50 values of 14 nM for RARα, β, and γ subtypes. Additionally, retinoic acid-d5 interacts with the peroxisome proliferator-activated receptor β/δ (PPARβ/δ) with a Kd of 17 nM and inhibits the transcription factor Nrf2 through RARα activation. This compound is essential for studies involving retinoid signaling and cell differentiation.
Retinoic acid-d5 is a deuterium-labeled derivative of retinoic acid, functioning as a selective retinoic acid receptor (RAR) agonist. It is crucial for cellular processes such as growth, differentiation, and organogenesis, demonstrating IC50 values of 14 nM for RARα, β, and γ subtypes. Additionally, retinoic acid-d5 interacts with the peroxisome proliferator-activated receptor β/δ (PPARβ/δ) with a Kd of 17 nM and inhibits the transcription factor Nrf2 through RARα activation. This compound is essential for studies involving retinoid signaling and cell differentiation.
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