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RGB-286638

CDK inhibitor

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Catalog No. A13130

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
RGB-286638 5mg A13130-5
€142.50
RGB-286638 10mg A13130-10
€237.50
RGB-286638 25mg A13130-25
€551.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.

RGB-286638

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Chemical Information

Catalog Num A13130
Actions Inhibitor
M. Wt 618.55
Formula C29H37Cl2N7O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 784210-87-3
Synonyms RGB286638, RGB 286638
SMILES COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6.Cl.Cl

Biological Activity

Description
RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.17 mL 80.83 mL 161.67mL
0.5 mM 3.23 mL 16.17 mL 32.33 mL
1 mM 1.62 mL 8.08 mL 16.17 mL
5 mM 0.32 mL 1.62 mL 3.23 mL

*The above data is based on the productmolecular weight 618.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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