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Biological Activity
RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.17 mL | 80.83 mL | 161.67 mL |
| 0.5 mM | 3.23 mL | 16.17 mL | 32.33 mL |
| 1 mM | 1.62 mL | 8.08 mL | 16.17 mL |
| 5 mM | 0.32 mL | 1.62 mL | 3.23 mL |
*The above data is based on the productmolecular weight 618.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13130 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 784210-87-3 |
| Formula | C29H37Cl2N7O4 |
| M. Wt | 618.55 |
| Purity | >98% |
| Synonyms | RGB286638, RGB 286638 |
| SMILES | COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6.Cl.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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