[Rh(cod)Cl]2 (Chloro(1,5-cyclooctadiene)rhodium(I) dimer) functions as an anti-platelet aggregation agent by inhibiting platelet-activating factor-mediated aggregation, with IC50 values of 5.2 μM in rabbit platelets and 43.3 μM in human platelet-rich plasma. It also inhibits thrombin-, ADP-, and collagen-induced aggregation, showing IC50 values of 16.7 μM, 162 μM, and 69.8 μM, respectively. This compound is valuable for research into cardiovascular diseases, particularly thrombosis.
[Rh(cod)Cl]2 (Chloro(1,5-cyclooctadiene)rhodium(I) dimer) functions as an anti-platelet aggregation agent by inhibiting platelet-activating factor-mediated aggregation, with IC50 values of 5.2 μM in rabbit platelets and 43.3 μM in human platelet-rich plasma. It also inhibits thrombin-, ADP-, and collagen-induced aggregation, showing IC50 values of 16.7 μM, 162 μM, and 69.8 μM, respectively. This compound is valuable for research into cardiovascular diseases, particularly thrombosis.
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