RI(dl)-2 is a potent inhibitor of RAD51, specifically targeting its D-loop activity with an IC50 of 11.1 µM, and effectively inhibiting homologous recombination (HR) with an IC50 of 3.0 µM. This compound disrupts HR-mediated repair of DNA double-strand breaks, leading to increased sensitivity in various cancer cell lines. RI(dl)-2 serves as a valuable tool for investigating HR processes and exploring potential therapeutic strategies in cancer research.
RI(dl)-2 is a potent inhibitor of RAD51, specifically targeting its D-loop activity with an IC50 of 11.1 µM, and effectively inhibiting homologous recombination (HR) with an IC50 of 3.0 µM. This compound disrupts HR-mediated repair of DNA double-strand breaks, leading to increased sensitivity in various cancer cell lines. RI(dl)-2 serves as a valuable tool for investigating HR processes and exploring potential therapeutic strategies in cancer research.
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