RITA (NSC 652287)

Name: RITA (NSC 652287)
Brand: Adooq Bioscience
SKU: A11931
Rating: 100 (1 reviews)

Catalog No.: A11931

p53 activator

Product Citations (1)

RITA (NSC 652287) Chemical Structure

CAS NO. 213261-59-7

RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.

Availability: In stock

Package	Price	Qty
5 mg	$70.00
10 mg	$120.00
25 mg	$240.00
50 mg	$400.00
10mM * 1mL in DMSO	$100.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq RITA (NSC 652287)

M Kobayashi, .et al. Nutlin-3a Suppresses Poly (ADP-ribose) Polymerase 1 by Mechanisms Different From Conventional PARP1 Suppressors in a Human Breast Cancer Cell Line, Oncotarget, 2020, May 5;11(18):1653-1665 PMID: 32405340

Biological Activity

RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.

Targets

Mdm2	p53

Solubility *

In vitro (25°C)	DMSO	56 mg/mL (191.53 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (27.36 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.2 mL	171 mL	342 mL
0.5 mM	6.84 mL	34.2 mL	68.4 mL
1 mM	3.42 mL	17.1 mL	34.2 mL
5 mM	0.68 mL	3.42 mL	6.84 mL

*The above data is based on the productmolecular weight 292.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11931
Actions	Activator
CAS No.	213261-59-7
Formula	C14H12O3S2
M. Wt	292.4
Solubility	DMSO
Purity	>99%
Synonyms	NSC652287, p53 Activator III
SMILES	C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.