RITA (NSC 652287)

Catalog No.: A11931

p53 activator

RITA (NSC 652287) Chemical Structure

CAS NO. 213261-59-7

RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
25 mg
$240.00
50 mg
$400.00
10mM * 1mL in DMSO
$100.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
Targets
Mdm2 p53
In vitro (25°C) DMSO 58 mg/mL (198.37 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL (27.36 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.2 mL 171 mL 342 mL
0.5 mM 6.84 mL 34.2 mL 68.4 mL
1 mM 3.42 mL 17.1 mL 34.2 mL
5 mM 0.68 mL 3.42 mL 6.84 mL

*The above data is based on the productmolecular weight 292.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11931
Actions Activator
M. Wt 292.4
Formula C14H12O3S2
Solubility DMSO
Purity >99%
Storage at -20°C 3 years Powder
CAS No. 213261-59-7
Synonyms NSC652287, p53 Activator III
SMILES C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO

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