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$0.00 - M Kobayashi, .et al. Nutlin-3a Suppresses Poly (ADP-ribose) Polymerase 1 by Mechanisms Different From Conventional PARP1 Suppressors in a Human Breast Cancer Cell Line, Oncotarget, 2020, May 5;11(18):1653-1665 PMID: 32405340
Biological Activity
RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
Targets
| Mdm2 | p53 | |||
| In vitro (25°C) | DMSO | 58 mg/mL (198.37 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 8 mg/mL (27.36 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.2 mL | 171 mL | 342 mL |
| 0.5 mM | 6.84 mL | 34.2 mL | 68.4 mL |
| 1 mM | 3.42 mL | 17.1 mL | 34.2 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
*The above data is based on the productmolecular weight 292.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11931 |
|---|---|
| Actions | Activator |
| M. Wt | 292.4 |
| Formula | C14H12O3S2 |
| Solubility | DMSO |
| Purity | >99% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 213261-59-7 |
| Synonyms | NSC652287, p53 Activator III |
| SMILES | C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO |
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