RLX-33 is a potent, selective, and blood-brain barrier-permeable antagonist of the relaxin family peptide 3 receptor (RXFP3), with an IC50 of 2.36 μM. It effectively inhibits relaxin-3-induced phosphorylation of ERK1 and ERK2, with IC50 values of 7.82 μM and 13.86 μM, respectively. RLX-33 suppresses RXFP3 agonist (R3/I5)-induced food intake in rats and is a valuable tool for metabolic syndrome research.
RLX-33 is a potent, selective, and blood-brain barrier-permeable antagonist of the relaxin family peptide 3 receptor (RXFP3), with an IC50 of 2.36 μM. It effectively inhibits relaxin-3-induced phosphorylation of ERK1 and ERK2, with IC50 values of 7.82 μM and 13.86 μM, respectively. RLX-33 suppresses RXFP3 agonist (R3/I5)-induced food intake in rats and is a valuable tool for metabolic syndrome research.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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