Ro 48-8071 fumarate

Catalog No.: A14321

Ro 48-8071 fumarate

Ro 48-8071 fumarate Chemical Structure

CAS NO. 189197-69-1

Ro 48-8071 inhibits cholesterol biosynthesis at the level of 2,3-oxidosqualene cyclase (OSC). It blocks OSC and cholesterol synthesis in HepG2 cells in the nanomolar range. A novel lipid lowering agent.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$200.00
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Biological Activity

Ro 48-8071 inhibits cholesterol biosynthesis at the level of 2,3-oxidosqualene cyclase (OSC). It blocks OSC and cholesterol synthesis in HepG2 cells in the nanomolar range. A novel lipid lowering agent.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.72 mL 88.59 mL 177.18 mL
0.5 mM 3.54 mL 17.72 mL 35.44 mL
1 mM 1.77 mL 8.86 mL 17.72 mL
5 mM 0.35 mL 1.77 mL 3.54 mL

*The above data is based on the productmolecular weight 564.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14321
CAS No. 189197-69-1
Formula C23H27NO2BrF.C4H4O4
M. Wt 564.4
Purity >98%
Synonyms Ro 488071, Ro488071
SMILES CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C.C(=C/C(=O)O)\C(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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