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Biological Activity
Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.79 mL | 88.97 mL | 177.94 mL |
| 0.5 mM | 3.56 mL | 17.79 mL | 35.59 mL |
| 1 mM | 1.78 mL | 8.9 mL | 17.79 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.56 mL |
*The above data is based on the productmolecular weight 561.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18820 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1673568-73-4 |
| Formula | C27H27ClF3N5O3 |
| M. Wt | 561.98 |
| Purity | >98% |
| Synonyms | KAR5417, KAR-5417, KAR 5417 |
| SMILES | O=C([C@H]1NCC2(CCN(C3=NC(N)=NC(O[C@H](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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