Rodatristat

Catalog No.: A18820

TPH1/TPH2 inhibitor

Rodatristat

Rodatristat Chemical Structure

CAS NO. 1673568-73-4

Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.79 mL 88.97 mL 177.94 mL
0.5 mM 3.56 mL 17.79 mL 35.59 mL
1 mM 1.78 mL 8.9 mL 17.79 mL
5 mM 0.36 mL 1.78 mL 3.56 mL

*The above data is based on the productmolecular weight 561.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18820
Actions Inhibitor
M. Wt 561.98
Formula C27H27ClF3N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1673568-73-4
Synonyms KAR5417, KAR-5417, KAR 5417
SMILES O=C([[email protected]]1NCC2(CCN(C3=NC(N)=NC(O[[email protected]](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O

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