RS-127445

Catalog No.: A11165

5-HT2B receptor antagonist

RS-127445

RS-127445 Chemical Structure

CAS NO. 199864-87-4

RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$70.00
50 mg
$200.00
100 mg
$320.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Takeshi Takayanagi, .et al. Serotonin 5-HT2B receptor antagonism is fundamental for protecting PC12 cells exposed to hydrogen peroxide, Fujita Medical Journal, 2015, 1(1), 1-5, 2015

Biological Activity

RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.

Targets
5-HT2B 5-HT2B
10.4(pIC50)9.5(pKi)
In vitro DMSO 54 mg/mL (191.94 mM)
Water Insoluble
Ethanol 8 mg/mL (28.43 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.55 mL 177.73 mL 355.45 mL
0.5 mM 7.11 mL 35.55 mL 71.09 mL
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL

*The above data is based on the productmolecular weight 281.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11165
Actions Antagonist
CAS No. 199864-87-4
Formula C17H16FN3
M. Wt 281.33
Purity >98%
Synonyms RS127445, MT 500, RS127,445
SMILES CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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