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- Takeshi Takayanagi, .et al. Serotonin 5-HT2B receptor antagonism is fundamental for protecting PC12 cells exposed to hydrogen peroxide, Fujita Medical Journal, 2015, 1(1), 1-5, 2015
Biological Activity
RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.
Targets
| 5-HT2B | 5-HT2B | |||
| 10.4(pIC50) | 9.5(pKi) |
| In vitro | DMSO | 54 mg/mL (191.94 mM) | |
| Water | Insoluble | ||
| Ethanol | 8 mg/mL (28.43 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.55 mL | 177.73 mL | 355.45 mL |
| 0.5 mM | 7.11 mL | 35.55 mL | 71.09 mL |
| 1 mM | 3.55 mL | 17.77 mL | 35.55 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.11 mL |
*The above data is based on the productmolecular weight 281.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11165 |
|---|---|
| Actions | Antagonist |
| CAS No. | 199864-87-4 |
| Formula | C17H16FN3 |
| M. Wt | 281.33 |
| Purity | >98% |
| Synonyms | RS127445, MT 500, RS127,445 |
| SMILES | CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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