RSV L-protein-IN-5 is a potent inhibitor of Respiratory syncytial virus (RSV), demonstrating an EC50 of 0.1 μM. This compound primarily targets the RSV polymerase, with an IC50 of 0.66 μM, effectively blocking mRNA synthesis by inhibiting the guanylation of viral transcripts. Despite exhibiting moderate cytotoxicity (CC50 of 10.7 μM in HEp-2 cells), RSV L-protein-IN-5 shows significant antiviral activity in preclinical mouse models of RSV infection, making it a valuable tool for RSV research and therapeutic development.
RSV L-protein-IN-5 is a potent inhibitor of Respiratory syncytial virus (RSV), demonstrating an EC50 of 0.1 μM. This compound primarily targets the RSV polymerase, with an IC50 of 0.66 μM, effectively blocking mRNA synthesis by inhibiting the guanylation of viral transcripts. Despite exhibiting moderate cytotoxicity (CC50 of 10.7 μM in HEp-2 cells), RSV L-protein-IN-5 shows significant antiviral activity in preclinical mouse models of RSV infection, making it a valuable tool for RSV research and therapeutic development.
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