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Biological Activity
RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-kB.
Targets
| Nrf2 | ||||
| In vitro (25°C) | DMSO | 98 mg/mL (176.66 mM) | |
| Water | Insoluble | ||
| Ethanol | 20 mg/mL (36.05 mM) | ||
| In vivo | 10%DMSO+90% Corn oil | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.03 mL | 90.14 mL | 180.27 mL |
| 0.5 mM | 3.61 mL | 18.03 mL | 36.05 mL |
| 1 mM | 1.8 mL | 9.01 mL | 18.03 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.61 mL |
*The above data is based on the productmolecular weight 554.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14417 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1474034-05-3 |
| Formula | C33H44F2N2O3 |
| M. Wt | 554.71 |
| Purity | >98% |
| Synonyms | RTA 408, RTA408 |
| SMILES | C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)NC(=O)C(C)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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