RTA-408

Catalog No.: A14417

Nrf2 inhibitor

RTA-408

RTA-408 Chemical Structure

CAS NO. 1474034-05-3

RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-kB.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$135.00
25 mg
$220.00
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Biological Activity

RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-kB.
Targets
Nrf2
In vitro (25°C) DMSO 98 mg/mL (176.66 mM)
Water Insoluble
Ethanol 20 mg/mL (36.05 mM)
In vivo 10%DMSO+90% Corn oil 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.14 mL 180.27 mL
0.5 mM 3.61 mL 18.03 mL 36.05 mL
1 mM 1.8 mL 9.01 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

*The above data is based on the productmolecular weight 554.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14417
Actions Inhibitor
CAS No. 1474034-05-3
Formula C33H44F2N2O3
M. Wt 554.71
Purity >98%
Synonyms RTA 408, RTA408
SMILES C[[email protected]@]12CC[[email protected]]3(CCC(C[[email protected]]3[[email protected]]1C(=O)C=C4[[email protected]]2(CC[[email protected]@H]5[[email protected]@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)NC(=O)C(C)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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