S-2 Methanandamide

Catalog No.: A59310
CB1 Receptor Agonist
S-2 Methanandamide is a potent agonist of the CB1 receptor, exhibiting an IC50 value of 173 nM in the presence of PMSF. It demonstrates significantly lower activity at the CB2 receptor, with an IC50 value of 8216 nM. This compound is primarily utilized in research applications investigating cannabinoid receptor signaling and the physiological effects of endocannabinoids.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionS-2 Methanandamide is a potent agonist of the CB1 receptor, exhibiting an IC50 value of 173 nM in the presence of PMSF. It demonstrates significantly lower activity at the CB2 receptor, with an IC50 value of 8216 nM. This compound is primarily utilized in research applications investigating cannabinoid receptor signaling and the physiological effects of endocannabinoids.
Product Information
Catalog NumA59310
FormulaC23H39NO2
Molecular Weight361.56
CAS Number157182-48-4
SMILESCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCC(O)C)=O
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