(S)-Baclofen hydrochloride is a selective GABAB receptor agonist that effectively crosses the blood-brain barrier and demonstrates oral bioactivity, with an IC50 of 1.77 μM for GABAB receptors and 1564 μM for GABAA receptors. This compound is primarily utilized in research focused on muscle disorders, including spasticity, providing insights into therapeutic strategies for modulating muscle tone and motor function.
(S)-Baclofen hydrochloride is a selective GABAB receptor agonist that effectively crosses the blood-brain barrier and demonstrates oral bioactivity, with an IC50 of 1.77 μM for GABAB receptors and 1564 μM for GABAA receptors. This compound is primarily utilized in research focused on muscle disorders, including spasticity, providing insights into therapeutic strategies for modulating muscle tone and motor function.
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