(S)-Baclofen is a potent GABAB receptor agonist that effectively crosses the blood-brain barrier and exhibits oral bioactivity. With an IC50 value of 1.77 μM for GABAB receptors and 1564 μM for GABAA receptors, (S)-Baclofen is instrumental in studying muscle disorders, particularly spasticity. Its role in modulating inhibitory neurotransmission makes it a valuable tool for neuroscientific and pharmacological research.
(S)-Baclofen is a potent GABAB receptor agonist that effectively crosses the blood-brain barrier and exhibits oral bioactivity. With an IC50 value of 1.77 μM for GABAB receptors and 1564 μM for GABAA receptors, (S)-Baclofen is instrumental in studying muscle disorders, particularly spasticity. Its role in modulating inhibitory neurotransmission makes it a valuable tool for neuroscientific and pharmacological research.
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