(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid is an E3 ligase ligand-linker conjugate designed to engage the cereblon (CRBN) E3 ubiquitin ligase. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by linking target proteins to the ubiquitin-proteasome system. Its application in targeted protein degradation research makes it a valuable tool for studying protein regulation and therapeutic interventions in various diseases.
(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid is an E3 ligase ligand-linker conjugate designed to engage the cereblon (CRBN) E3 ubiquitin ligase. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by linking target proteins to the ubiquitin-proteasome system. Its application in targeted protein degradation research makes it a valuable tool for studying protein regulation and therapeutic interventions in various diseases.
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