(S)-LY-3381916 is a selective inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1), demonstrating potent activity with an IC50 value of less than 1.5 µM. This S-isomer effectively binds to the apo-IDO1 form, targeting the enzyme in its unbound state and circumventing the heme-bound variant. Research applications include investigating the role of IDO1 in immunoregulation and exploring therapeutic strategies in cancer and inflammatory diseases.
(S)-LY-3381916 is a selective inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1), demonstrating potent activity with an IC50 value of less than 1.5 µM. This S-isomer effectively binds to the apo-IDO1 form, targeting the enzyme in its unbound state and circumventing the heme-bound variant. Research applications include investigating the role of IDO1 in immunoregulation and exploring therapeutic strategies in cancer and inflammatory diseases.
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