S-N6-Methyladenosylhomocysteine is a potent inhibitor of the histone methyltransferase DOT1L, exhibiting an IC50 value of 0.29 μM. By selectively targeting DOT1L, this compound plays a crucial role in cancer research, particularly in studies investigating the epigenetic regulation and its implications in oncogenesis. It serves as a valuable tool for understanding the biochemical pathways associated with methylation-driven cancers and may facilitate the development of therapeutic strategies.
S-N6-Methyladenosylhomocysteine is a potent inhibitor of the histone methyltransferase DOT1L, exhibiting an IC50 value of 0.29 μM. By selectively targeting DOT1L, this compound plays a crucial role in cancer research, particularly in studies investigating the epigenetic regulation and its implications in oncogenesis. It serves as a valuable tool for understanding the biochemical pathways associated with methylation-driven cancers and may facilitate the development of therapeutic strategies.
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