(S,R,S)-AHPC-C2-PEG4-N3 is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology, featuring the (S,R,S)-AHPC-based VHL ligand and a four-unit PEG linker. This reagent enables the synthesis of vRucaparib-TP4, a potent PARP1 degrader with a DC50 of 82 nM. Additionally, (S,R,S)-AHPC-C2-PEG4-N3 contains an azide group, facilitating click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) or strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its applications include targeted protein degradation and advanced chemical biology research.
(S,R,S)-AHPC-C2-PEG4-N3 is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology, featuring the (S,R,S)-AHPC-based VHL ligand and a four-unit PEG linker. This reagent enables the synthesis of vRucaparib-TP4, a potent PARP1 degrader with a DC50 of 82 nM. Additionally, (S,R,S)-AHPC-C2-PEG4-N3 contains an azide group, facilitating click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) or strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its applications include targeted protein degradation and advanced chemical biology research.
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