(S,R,S)-AHPC-C3-NH2 TFA

Catalog No.: A80069
E3 Ligase Ligand-linker Conjugate
(S,R,S)-AHPC-C3-NH2 TFA is an E3 ligase ligand-linker conjugate designed for use in proteolysis-targeted chimera (PROTAC) technology. This compound features the VH032-derived VHL ligand, facilitating targeted degradation of specific substrates. It is instrumental in synthesizing various PROTACs, including UNC6852, which targets EED for bivalent degradation, making it valuable for studies in cellular regulation and protein homeostasis.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(S,R,S)-AHPC-C3-NH2 TFA is an E3 ligase ligand-linker conjugate designed for use in proteolysis-targeted chimera (PROTAC) technology. This compound features the VH032-derived VHL ligand, facilitating targeted degradation of specific substrates. It is instrumental in synthesizing various PROTACs, including UNC6852, which targets EED for bivalent degradation, making it valuable for studies in cellular regulation and protein homeostasis.
Product Information
Catalog NumA80069
FormulaC28H38F3N5O6S
Molecular Weight629.69
CAS Number2688842-02-4
SMILESOC(C(F)(F)F)=O.NCCCC(N[C@H](C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C(C)(C)C)=O
SynonymsVH032-C3-NH2 TFA
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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