(S,R,S)-AHPC-C5-PEG3-C3

Catalog No.: A80351
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-C5-PEG3-C3 is an E3 ligase ligand-linker conjugate designed to facilitate the targeted degradation of proteins via the PROTAC (Proteolysis Targeting Chimeras) technology. This compound incorporates a VHL ligand and a PEG-based linker derived from (S,R,S)-AHPC, providing enhanced solubility and stability. Its applications include the development of novel therapeutic strategies for diseases associated with protein dysregulation.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(S,R,S)-AHPC-C5-PEG3-C3 is an E3 ligase ligand-linker conjugate designed to facilitate the targeted degradation of proteins via the PROTAC (Proteolysis Targeting Chimeras) technology. This compound incorporates a VHL ligand and a PEG-based linker derived from (S,R,S)-AHPC, providing enhanced solubility and stability. Its applications include the development of novel therapeutic strategies for diseases associated with protein dysregulation.
Product Information
Catalog NumA80351
FormulaC38H61N5O7S
Molecular Weight731.99
CAS Number2421187-84-8
SMILESC([C@@H](NC(CCCCCOCCOCCOCCCCCCN)=O)[C@@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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