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(S,R,S)-AHPC-C6-PEG3-C4-Cl

Catalog No.: A79958
E3 ligase ligand-linker conjugate
(S,R,S)-AHPC-C6-PEG3-C4-Cl is an E3 ligase ligand-linker conjugate designed for targeted protein degradation. This compound features the (S,R,S)-AHPC-based VHL ligand linked via a 20-atom length alkyl/ether linker that includes a halogen group. (S,R,S)-AHPC-C6-PEG3-C4-Cl is effective in promoting the degradation of GFP-HaloTag7 in cell-based assays, facilitating research in protein turnover, cellular signaling, and therapeutic target modulation.
(S,R,S)-AHPC-C6-PEG3-C4-Cl 1835705-55-9 E3 ligase ligand-linker conjugate
Grouped product items
Size Price Stock Qty
2mg
$50.00
In stock
5mg
$80.00
In stock
50mg
$280.00
In stock
100mg
$440.00
In stock
500mg
$1,520.00
In stock
1g
$2,615.00
In stock
2g
$3,820.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(S,R,S)-AHPC-C6-PEG3-C4-Cl is an E3 ligase ligand-linker conjugate designed for targeted protein degradation. This compound features the (S,R,S)-AHPC-based VHL ligand linked via a 20-atom length alkyl/ether linker that includes a halogen group. (S,R,S)-AHPC-C6-PEG3-C4-Cl is effective in promoting the degradation of GFP-HaloTag7 in cell-based assays, facilitating research in protein turnover, cellular signaling, and therapeutic target modulation.
Product Information
Catalog NumA79958
FormulaC38H59ClN4O7S
Molecular Weight751.42
CAS Number1835705-55-9
SMILESO=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
SynonymsVH032-C6-PEG3-C4-Cl; VHL Ligand-Linker Conjugates 12; E3 ligase Ligand-Linker Conjugates 8
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PROTAC > E3 Ligase Ligand-Linker Conjugate