(S,R,S)-AHPC-CO-PEG-C2-iodine

Catalog No.: A80230
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-CO-PEG-C2-iodine is a specifically designed E3 ligase ligand-linker conjugate that targets the VHL E3 ubiquitin ligase. This compound facilitates the synthesis of PROTACs, which are engineered to induce targeted protein degradation. It is particularly useful in the development of PROTACs like the FAK degrader 1, enabling researchers to investigate the therapeutic potential of targeted protein degradation in various biological contexts.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
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Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
Description(S,R,S)-AHPC-CO-PEG-C2-iodine is a specifically designed E3 ligase ligand-linker conjugate that targets the VHL E3 ubiquitin ligase. This compound facilitates the synthesis of PROTACs, which are engineered to induce targeted protein degradation. It is particularly useful in the development of PROTACs like the FAK degrader 1, enabling researchers to investigate the therapeutic potential of targeted protein degradation in various biological contexts.
Product Information
Catalog NumA80230
FormulaC27H37IN4O5S
Molecular Weight656.58
CAS Number3057447-11-4
SMILESICCOCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O
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