(S,R,S)-AHPC-Me-CO-C6-COOH

Catalog No.: A80347
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate featuring a VHL ligand and a linker derived from (S,R,S)-AHPC. This compound facilitates the synthesis of PROTAC molecules, enabling targeted protein degradation. The unique structure promotes selective ubiquitination and subsequent proteasomal degradation of target proteins, providing valuable tools for research in protein regulation and disease model studies.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate featuring a VHL ligand and a linker derived from (S,R,S)-AHPC. This compound facilitates the synthesis of PROTAC molecules, enabling targeted protein degradation. The unique structure promotes selective ubiquitination and subsequent proteasomal degradation of target proteins, providing valuable tools for research in protein regulation and disease model studies.
Product Information
Catalog NumA80347
FormulaC31H44N4O6S
Molecular Weight600.78
CAS Number2365173-02-8
SMILESC([C@@H](NC(CCCCCCC(O)=O)=O)[C@@](C)(C)C)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
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