(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc

Catalog No.: A80077
E3 Ligase Ligand-Linker Lonjugate
(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc is an E3 ligase ligand-linker conjugate designed to facilitate targeted protein degradation through the EED pathway. This compound effectively engages E3 ligases, enabling the development of PROTACs (proteolysis-targeting chimeras) for precise modulation of protein levels in various biological systems. Its utility spans applications in chemical biology and therapeutic research focused on protein degradation and regulation.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc is an E3 ligase ligand-linker conjugate designed to facilitate targeted protein degradation through the EED pathway. This compound effectively engages E3 ligases, enabling the development of PROTACs (proteolysis-targeting chimeras) for precise modulation of protein levels in various biological systems. Its utility spans applications in chemical biology and therapeutic research focused on protein degradation and regulation.
Product Information
Catalog NumA80077
FormulaC37H49N5O8S
Molecular Weight723.88
CAS Number2409007-40-3
SMILESCC(C)([C@H](NC(COC1=CC=C(OCCNC(OC(C)(C)C)=O)C=C1)=O)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C=C3)C4=C(N=CS4)C)=O)=O)C
SynonymsVH032-O-Ph-PEG1-NH-Boc
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