(S,R,S)-AHPC-PEG3-N3 is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology. This compound features the (S,R,S)-AHPC-based VHL ligand and a three-unit PEG linker, enabling efficient conjugation for targeted protein degradation. The presence of an azide group allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules or those featuring DBCO or BCN groups. Its applications include the development of targeted therapeutics and exploring the dynamics of protein regulation in various biological systems.
(S,R,S)-AHPC-PEG3-N3 is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology. This compound features the (S,R,S)-AHPC-based VHL ligand and a three-unit PEG linker, enabling efficient conjugation for targeted protein degradation. The presence of an azide group allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules or those featuring DBCO or BCN groups. Its applications include the development of targeted therapeutics and exploring the dynamics of protein regulation in various biological systems.
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