(S,R,S)-AHPC TFA
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Important Notice: For research use only. We do not sell to patients.
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Discription | (S,R,S)-AHPC TFA (MDK7526 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA (MDK7526 TFA) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. | ||
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Catalog Num | A19593 |
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Formula | C24H31F3N4O5S |
Molecular Weight | 544.59 |
CAS Number | 1631137-51-3 |
SMILES | FC(F)(F)C(O)=O.O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2 |
Synonyms | MDK7526 TFA, MDK 7526, MDK-7526; VH032-NH2 TFA; VHL ligand 1 TFA |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2