(S)-Seco-Duocarmycin SA is a potent DNA alkylator that binds to DNA, leading to cytotoxic effects in tumor cells. This compound exhibits significant antitumor activity, with an IC50 of 10 pM, and induces a concentration-dependent increase in apoptotic cell death. Additionally, (S)-Seco-Duocarmycin SA is capable of causing substantial cell cycle arrest in the S and G2/M phases. Its mechanism of action makes it a valuable cytotoxic agent for antibody-drug conjugates in cancer research applications.
(S)-Seco-Duocarmycin SA is a potent DNA alkylator that binds to DNA, leading to cytotoxic effects in tumor cells. This compound exhibits significant antitumor activity, with an IC50 of 10 pM, and induces a concentration-dependent increase in apoptotic cell death. Additionally, (S)-Seco-Duocarmycin SA is capable of causing substantial cell cycle arrest in the S and G2/M phases. Its mechanism of action makes it a valuable cytotoxic agent for antibody-drug conjugates in cancer research applications.
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