SB 218078

Catalog No.: A15480

Chk1 Inhibitor

SB 218078

SB 218078 Chemical Structure

CAS NO. 135897-06-2

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively)

Availability: In stock

Package Price Qty
2 mg
$100.00
5 mg
$200.00
10 mg
$320.00
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Biological Activity

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.42 mL 127.1 mL 254.2 mL
0.5 mM 5.08 mL 25.42 mL 50.84 mL
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15480
Actions Inhibitor
CAS No. 135897-06-2
Formula C24H15N3O3
M. Wt 393.39
Solubility DMSO
Purity >98%
Synonyms SB218078, SB-218078
SMILES C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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