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SB 218078


Chk1 Inhibitor

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Catalog No. A15480

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SB 218078 2mg A15480-2

Regular Price: $100.00

Special Price: $90.00

SB 218078 5mg A15480-5

Regular Price: $200.00

Special Price: $180.00

SB 218078 10mg A15480-10

Regular Price: $320.00

Special Price: $288.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively)

SB 218078

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Chemical Information

Catalog Num A15480
Actions Inhibitor
M. Wt 393.39
Formula C24H15N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 135897-06-2
Synonyms SB218078, SB-218078
SMILES code C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
Chemical Name 9,10,11,12,-Tetrahydro-9,12-epoxy-1H-diindolo(1,2,3-fg:3′,2′,1′-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2H)-dione

Biological Activity

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively)

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.42 mL 127.1 mL 254.2mL
0.5 mM 5.08 mL 25.42 mL 50.84 mL
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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