SB 258741

Catalog No.: A29895
5-HT7 Antagonist
SB 258741 is a selective antagonist of the 5-HT7 receptor, exhibiting a high affinity with a pKi of 8. This compound has demonstrated significant potential in studying serotonin-related pathways, making it valuable for research focused on mood disorders and other neuropsychiatric conditions. Its specificity for the 5-HT7 receptor allows for targeted investigations into receptor signaling and therapeutic applications.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSB 258741 is a selective antagonist of the 5-HT7 receptor, exhibiting a high affinity with a pKi of 8. This compound has demonstrated significant potential in studying serotonin-related pathways, making it valuable for research focused on mood disorders and other neuropsychiatric conditions. Its specificity for the 5-HT7 receptor allows for targeted investigations into receptor signaling and therapeutic applications.
Product Information
Catalog NumA29895
FormulaC19H30N2O2S
Molecular Weight350.52
CAS Number201038-58-6
SMILESO=S(N1[C@@H](CCN2CCC(C)CC2)CCC1)(C3=CC=CC(C)=C3)=O
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