SB-267268 is a selective antagonist of αvβ3 and αvβ5 integrins, demonstrating inhibition constants (Kis) of 0.9 nM, 0.5 nM, and 0.7 nM for human αvβ3, monkey αvβ3, and human αvβ5, respectively. This compound effectively inhibits angiogenesis, showcasing IC50 values of 0.68 nM for human αvβ3 and 0.29 nM for mouse αvβ3. SB-267268 is a valuable tool for research focused on vascular biology, cancer therapeutics, and the modulation of integrin signaling pathways.
SB-267268 is a selective antagonist of αvβ3 and αvβ5 integrins, demonstrating inhibition constants (Kis) of 0.9 nM, 0.5 nM, and 0.7 nM for human αvβ3, monkey αvβ3, and human αvβ5, respectively. This compound effectively inhibits angiogenesis, showcasing IC50 values of 0.68 nM for human αvβ3 and 0.29 nM for mouse αvβ3. SB-267268 is a valuable tool for research focused on vascular biology, cancer therapeutics, and the modulation of integrin signaling pathways.
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