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SB 399885 hydrochloride is a potent, brain penetrant, and orally active SR-6 antagonist. It displays > 200-fold selectivity for SR-6 over other serotonin receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human SR-6 receptors, respectively).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.4 mL | 112.02 mL | 224.04 mL |
| 0.5 mM | 4.48 mL | 22.4 mL | 44.81 mL |
| 1 mM | 2.24 mL | 11.2 mL | 22.4 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
*The above data is based on the productmolecular weight 446.353. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14102 |
|---|---|
| Actions | Antagonist |
| CAS No. | 402713-80-8 |
| Formula | C18H21Cl2N3O4S |
| M. Wt | 446.353 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | SB399885, SB-399885 |
| SMILES | COC1=C(C=C(C=C1)S(=O)(=O)NC2=CC(=CC(=C2OC)Cl)Cl)N3CCNCC3.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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