Catalog No.: A14092

5-HT6 receptor antagonist


SB-742457 Chemical Structure

CAS NO. 607742-69-8

SB-742457 is a selective 5-HT6 receptor antagonist with cognition, memory, and learning-enhancing effects.

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5 mg
10 mg
25 mg
10mM * 1mL in DMSO
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Biological Activity

SB-742457 is a selective 5-HT6 receptor antagonist with cognition, memory, and learning-enhancing effects.
In vitro (25°C) DMSO 72 mg/mL (203.7 mM)
Water Insoluble
Ethanol 2 mg/mL (5.65 mM)
In vivo 2% DMSO, 48% PEG300, 2% Tween 80 and 48% water 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.29 mL 141.47 mL 282.93 mL
0.5 mM 5.66 mL 28.29 mL 56.59 mL
1 mM 2.83 mL 14.15 mL 28.29 mL
5 mM 0.57 mL 2.83 mL 5.66 mL

*The above data is based on the productmolecular weight 353.444. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14092
Actions Antagonist
CAS No. 607742-69-8
Formula C19H19N3O2S
M. Wt 353.444
Purity >98%
Synonyms GSK 742457, SB742457, SB 742457, GSK742457, SB-742,457

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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