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Biological Activity
SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.
Targets
B-Raf (Cell-free assay) | ||||
0.16 nM(Ki) |
In vitro (25°C) | DMSO | 5 mg/mL (11.02 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.05 mL | 110.25 mL | 220.51 mL |
0.5 mM | 4.41 mL | 22.05 mL | 44.1 mL |
1 mM | 2.21 mL | 11.03 mL | 22.05 mL |
5 mM | 0.44 mL | 2.21 mL | 4.41 mL |
*The above data is based on the productmolecular weight 453.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10829 |
---|---|
Actions | Inhibitor |
CAS No. | 405554-55-4 |
Formula | C27H27N5O2 |
M. Wt | 453.5 |
Purity | >98% |
Synonyms | SB-590885 |
SMILES | CN(C)CCOC1=CC=C(C=C1)C2=N/C(=C\3/C=CC4=C(CCC4=C3)N=O)/C(=C5C=CNC=C5)N2 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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