SB590885

Name: SB590885
Brand: Adooq Bioscience
SKU: A10829
Rating: 100 (268 reviews)

Catalog No.: A10829

B-Raf Inhibitor

SB590885 Chemical Structure

CAS NO. 405554-55-4

SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$136.00
50 mg	$450.00
100 mg	$750.00
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Biological Activity

SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.

Targets

B-Raf (Cell-free assay)
0.16 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	5 mg/mL (11.02 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.05 mL	110.25 mL	220.51 mL
0.5 mM	4.41 mL	22.05 mL	44.1 mL
1 mM	2.21 mL	11.03 mL	22.05 mL
5 mM	0.44 mL	2.21 mL	4.41 mL

*The above data is based on the productmolecular weight 453.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10829
Actions	Inhibitor
CAS No.	405554-55-4
Formula	C27H27N5O2
M. Wt	453.5
Purity	>98%
Synonyms	SB-590885
SMILES	CN(C)CCOC1=CC=C(C=C1)C2=N/C(=C\3/C=CC4=C(CCC4=C3)N=O)/C(=C5C=CNC=C5)N2
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.