SB590885

Catalog No.: A10829

B-Raf Inhibitor

SB590885

SB590885 Chemical Structure

CAS NO. 405554-55-4

SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$136.00
50 mg
$450.00
100 mg
$750.00
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Biological Activity

SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.
Targets
B-Raf (Cell-free assay)
0.16 nM(Ki)
In vitro (25°C) DMSO 5 mg/mL (11.02 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.05 mL 110.25 mL 220.51 mL
0.5 mM 4.41 mL 22.05 mL 44.1 mL
1 mM 2.21 mL 11.03 mL 22.05 mL
5 mM 0.44 mL 2.21 mL 4.41 mL

*The above data is based on the productmolecular weight 453.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10829
Actions Inhibitor
CAS No. 405554-55-4
Formula C27H27N5O2
M. Wt 453.5
Purity >98%
Synonyms SB-590885
SMILES CN(C)CCOC1=CC=C(C=C1)C2=N/C(=C\3/C=CC4=C(CCC4=C3)N=O)/C(=C5C=CNC=C5)N2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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