SCH 51866 is a potent and selective inhibitor of phosphodiesterase 1 (PDE1) and phosphodiesterase 5 (PDE5), with IC50 values of 70 nM and 60 nM, respectively. This compound effectively inhibits collagen-induced aggregation of human washed platelets with an IC50 of 10 μM and demonstrates protective effects against neointimal formation in balloon catheter-injured carotid arteries in spontaneously hypertensive rats. Additionally, SCH 51866 has been shown to reduce blood pressure in this model, making it a valuable tool for research in hypertension and related vascular disorders.
SCH 51866 is a potent and selective inhibitor of phosphodiesterase 1 (PDE1) and phosphodiesterase 5 (PDE5), with IC50 values of 70 nM and 60 nM, respectively. This compound effectively inhibits collagen-induced aggregation of human washed platelets with an IC50 of 10 μM and demonstrates protective effects against neointimal formation in balloon catheter-injured carotid arteries in spontaneously hypertensive rats. Additionally, SCH 51866 has been shown to reduce blood pressure in this model, making it a valuable tool for research in hypertension and related vascular disorders.
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